細胞生物学

微生物生命体動態グループでは、微生物細胞が環境摂動にどのように適応するのかについて、細胞微生物学、ナノ・マイクロ流体デバイス、生細胞イメージングを組み合わせて探求します。

Centrioles are ancient cell organelles that localize at the core of centrosomes, playing essential roles in cell division and the formation of cilia and flagella. Centrioles have beautiful nine-fold symmetric structures that duplicate once per cell cycle in a process reminiscent of DNA replication.

The Marine Structural Biology Unit uses cryoelectron tomography and single particle cryoelectron microscopy to understand various aspects of coral biology in unprecedented detail.

The biological nonlinear dynamics data science unit investigates complex systems explicitly taking into account the role of time. We do this by instead of averaging occurrences using their statistics, we treat observations as frames of a movie and if patterns reoccur then we can use their behaviors in the past to predict their future. In most cases the systems that we study are part of complex networks of interactions and cover multiple scales. These include but are not limited to systems neuroscience, gene expression, posttranscriptional regulatory processes, to ecology, but also include societal and economic systems that have complex interdependencies. The processes that we are most interested in are those where the data has a particular geometry known as low dimensional manifolds. These are geometrical objects generated from embeddings of data that allows us to predict their future behaviors, investigate causal relationships, find if a system is becoming unstable, find early warning signs of critical transitions or catastrophes and more. Our computational approaches are based on tools that have their origin in the generalized Takens theorem, and are collectively known as empirical dynamic modeling (EDM). As a lab we are both a wet and dry lab where we design wet lab experiments that maximize the capabilities of our mathematical methods. The results from this data driven science approach then allows us to generate mechanistic hypotheses that can be again tested experimentally for empirical confirmation. This approach merges traditional hypothesis driven science and the more modern Data driven science approaches into a single virtuous cycle of discovery.

Every day, millions of cells in our body divide to maintain essential tissue functions. Errors in cell division can lead to developmental disorders or cancer. The research of the unit is focused on molecular mechanisms of cell divison and quality control in normal and cancer cells to understand tumor-suppressive mechanisms and identify biomarkers that confer a cancer-specific vulnerability to chemical drugs. The unit combines high throughput imaging, gene editing and genome wide screens to open new avenues for therapeutic development.

1分子イメジング・解析法の方法開発を推進し、また、それらの新しい方法を応用して、細胞膜がシグナル伝達とシナプス伝達をおこなう機構を解明することを目指しています。

分子神経科学ユニットは、生理的および病理的な状態における神経細胞体と軸索末端間での細胞内輸送のメカニズムを解明するための研究を行っています。

神経回路ユニットでは、分子生物学、マウス遺伝学、電気生理学、光遺伝学、行動解析などを用いて、運動系の神経回路の研究を進めています。

人間の体は約37兆個の細胞からなり、全ての細胞は細胞膜で包まれています。我々は細胞膜の傷と老化との関連を研究しています。

進化・細胞・共生の生物学ユニットでは、細胞の起源や進化における共生の相互作用の影響について研究しています。

細胞シグナルユニットでは、マウスモデルを用いながら、がん、神経疾患、免疫疾患、および糖尿病、肥満などの様々な疾患の原因を分子レベルで解明しようとしています。その...

細胞分裂動態ユニットでは、ヒト培養細胞とメダカ初期胚を用いて、遺伝情報の継承と初期発生の仕組みについて、特に紡錘体に焦点を当てて研究しています。

神経発生ユニットでは、ゼブラフィッシュの網膜をモデルに、神経細胞の分化、神経回路形成、神経変性と神経再生を制御するメカニズムについて研究しています。