Biophysics of Cellular Membranes

Course Aim

This lecture series introduces the basic concepts and current research in cellular biophysics of biological membrane systems.
この講義では、生体膜系の細胞生物物理学について、基本概念および最近の研究について概説する。

Course Description

More than half of cellular reactions occur within or on the surface of the membrane, including the plasma membrane, endomembranes, and various vesicles. Explore cell membrane biophysical and physicochemical processes including thermal conformational fluctuation, thermal diffusion, phase separation, and surface prewetting, and consider how cells might take advantage of these processes to enable their signaling functions in cellular biology, immunology, neurobiology, and in cancer. A combination of lectures and student presentations on these subjects is complemented by experiments on direct visualization of receptors and downstream signaling molecules at the level of single molecules in live cells, providing the basis for the studies of these research fields. This interdisciplinary field combines aspects of cell biology, chemistry, and physics, and welcomes students from across these disciplines.

Assessment

Report 50%; Final exam 50%

Prerequisites or Prior Knowledge

Biology, chemistry, and/or physics at undergraduate levels

Textbooks

Mary Luckey, Membrane Structural Biology 2nd Ed. Cambridge University Press

Reference Books

original papers will be supplied as required

Research Specialties