Stream 2. Healthy Individual

Healthy Individual advances the goal of healthy longevity by addressing health from the cellular to the systems level. Research targets the mechanisms of aging and neurodegeneration, including cellular senescence and astrocyte-driven brain decline, while also pursuing therapeutic strategies to preserve function. In parallel, the Stream develops improved and affordable diagnostics—such as lab-on-a-chip biosensors for daily stress monitoring and biomarker assays for ALS—that make early detection more accessible. Complementing these projects, multi-omics and microbiome studies provide a complex systems perspective, uncovering hidden interactions across biological layers that regulate resilience and decline. Together, these initiatives form an integrated framework for extending health span, linking molecular insights, systemic balance, and innovative diagnostics to support lifelong well-being.

Photograph of a smartphone held above a glass of water against a natural background. A small device is attached to the bottom of the smartphone.
Miniaturized Lab-on-a-Chip Devices for Precision Diagnosis
Professor Yukiko Goda and team unit
Overcoming Aging and Dementia by Focusing on Glial Cells
Professor Keiko Kono and unit
Healthy Aging by Ameliorating Plasma Membrane Damage
2 researchers working in a lab
Multinational Deep Phenotyping Using Multi-omics and Microbiome Data
Terenzio and unit member
Development of Biomarker-based Diagnostic Tools for ALS

Partner (Academic)

  • University of Melbourne (Australia)
  • The Weizmann Institute of Science (Israel)
  • Catalan Institute of Nanoscience and Nanotechnology (Spain)
  • Ulster University (U.K.)

Partner (Business)

  • SUNTORY (Japan)
  • Corundum Systems Biology, Inc. (Japan)
  • Nutrix AG (Switzerland)
  • NTT, Inc. (Japan)