The research focuses on understanding how cells age and how this knowledge could support healthy aging. To investigate this, the team studies cellular senescence, aiming to uncover the fundamental mechanism that causes cells to age in response to mechanical stress. Although senescent cells can support processes such as wound healing, their accumulation can contribute to persistent inflammation and age-related diseases.
The team investigates how damage to the plasma membrane triggers cellular senescence and how these cells may be linked to age-related diseases, including osteoarthritis and pulmonary fibrosis. Building on this research, they are studying molecules that can slow down senescence or inhibit inflammation. They are assessing whether these molecules could eventually be used in humans to slow the aging process or treat age-related diseases.
By connecting a better understanding of cellular aging with potential approaches to reducing its effects on health, the project aims to contribute to healthy longevity. In the longer term, this work could help people remain active and independent for more of their lives. The emphasis is on supporting more years in good health.
