Suppression of the mRNA turn-over leads to necroptosis
Intact CCR4-NOT complex (on the left) suppresses the messenger RNAs (mRNAs) encoding RIPK1 and RIPK3 proteins, thereby aiding cell survival. CNOT3-depleted cells, in which the CCR4-NOT complex does not function (on the right), reveal increased expression and stability of these mRNAs. This leads to build-up of death-triggering proteins and cell demise.
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