Genetics

Centrioles are ancient cell organelles that localize at the core of centrosomes, playing essential roles in cell division and the formation of cilia and flagella. Centrioles have beautiful nine-fold symmetric structures that duplicate once per cell cycle in a process reminiscent of DNA replication.

Every day, millions of cells divide to sustain essential tissue functions. Errors in this process can lead to developmental disorders or cancer. Our research focuses on the molecular mechanisms of cell division and quality control in both normal and cancer cells, aiming to uncover how cells maintain genomic stability and regulate proliferation. By integrating high-throughput imaging, gene editing, and genome-wide screening, we seek to expand our understanding of these fundamental processes and how their dysregulation contributes to cancer. Our lab is driven by a curiosity-based approach, grounded in the belief that fundamental research is essential for uncovering the principles that govern life. By investigating the intricate mechanisms controlling cell division, genome maintenance, and cellular quality control, we aim to reveal how these processes go awry in cancer. Through this knowledge, we strive to identify cancer-specific vulnerabilities, discover novel biomarkers, and open new avenues for targeted therapeutic strategies.

Neural Circuit Unit studies motor circuits using various techniques such as molecular biology, mouse genetics, trans-synaptic viruses, optogenetic, and chemogenetic tools.

The major goal of our research is to understand biological significance of epigenetic regulation of genes and transposons for environmental adaptation and genome evolution in plants.

The Genomics and Regulatory Systems Unit combines computational and experimental methods to study principles of gene regulation during early organismal development, using Oikopleura dioica as a model organism.

Developmental Neurobiology Unit uses zebrafish retina as a model to study mechanisms that control neuronal differentiation and circuit formation, and neuronal degeneration and regeneration.

The Cell Division Dynamics Unit studies the mechanisms of chromosome segregation and cell fate determination during mitosis with a focus on mitotic spindle assembly and positioning in cultured human cells and Medaka embryos.