Alexander Mikheyev and Mandy Tin
Protein Folding and Random Matrix Theory
Working in OIST’s interdisciplinary environment, Professor Shinobu Hikami, head of the Mathematical and Theoretical Physics Unit, has become especially interested in using random matrix theory to uncover correlations in complex biological systems, particularly in the intricate folding and entanglement of amino acid chains – an important process which eventually leads to a three-dimension protein, the building block of body tissue.
Spiny Neurons Receive Dopamine
The dendrite branches of spiny neurons are littered with spines, or receptor sites, for neurotransmitters, including dopamine. Spiny neurons play a crucial role in initiating and regulating movements of the body, limbs, and eyes by receiving signals from neurons in other parts of the brain that produce dopamine. The Brain Mechanism for Behaviour Unit is studying these cells in order to understand their role in Parkinson’s disease. Gordon Arbuthnott, head of the Unit, had previously found that half of these spines are lost from the dendrites when dopamine is removed, as is the case in Parkinson’s.
Figure 1. Relationship between corals and Symbiodinium in the supergroups of eukaryotes
The Marine Genomics Unit of OIST has decoded the genome of the algae Symbiodinium minutum. The paper was published in the online version of Current Biology on July 11. This is a major advance in understanding the complex ecology of coral reefs.