Effects of Topo II-Targeting Cancer Drugs

31 Jan 2019
Nicoletta Lanese

With DNA topoisomerase II (topo II) intact, DNA in fission yeast cells replicates normally and is split evenly between two daughter cells (left). When under the effects of anti-cancer drug ICRF-193, the DNA becomes tangled in the center of the parent cell, preventing its clean division.

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