Transitions of tonic inhibition in cerebellar granule cells during adolescence

A scientific figure showing the different pathway of tonic inhibition.

Transitions of tonic inhibition in cerebellar granule cells during adolescence. Astrocyte-released GABA (green) increases, spillover GABA (red) from inhibitory neurons (Golgi cells) decreases, while GABA uptake by transporters (blue) becomes more effective. A set point voltage (reversal potential) for GABA-activated inhibitory current decreases, enhancing GABA’s inhibitory action.

Date:
09 March 2026
Credit:
Kwon, J. et al., 2026

Copyright OIST (Okinawa Institute of Science and Technology Graduate University, 沖縄科学技術大学院大学). Creative Commons Attribution 4.0 International License (CC BY 4.0).

Download full-resolution image
Share on:
x icon facebook icon linkedin icon mail icon

Related Images

Prof. Yabing Qi introducing his research to Minister Ishihara (June 29, 2013)

On June 29 and 30, the International Conference on Climate Change and Coral Reef Conservation (organized by the Ministry of Environment and Okinawa Prefecture with the support of OIST and the University of the Ryukyus) was held at the OIST campus. Environment Minister Nobuteru Ishihara was guided around the OIST campus and visited the Energy Materials and Surface Sciences Unit (led by Prof. Yabing Qi), in which new solar energy materials are being developed. He also stopped by at the Marine Genomics Unit (led by Prof. Noriyuki Satoh), which conducts genome research of marine organisms such as corals.

Comparison between computational modeling and actual embryo on gene regulation in the entire fruit fly embryo

  Dr. Garth Ilsley, in Prof Nicholas Luscombe’s Genomics and Regulatory Systems Unit at OIST and Assistant Professor Angela DePace at Harvard Medical School succeeded in modelling early regulation of development in the fruit fly Drosophila using a statistical approach that accurately predicts gene expression in the whole embryo. This study was published in the open access journal, eLIFE, on August 6th. This figure is comparison of calculated results from the model (upper half) with image data from an actual embryo (lower half). It can be seen that the mutations in stripes 3 and 7 due to the misexpression of kni (A) and hb (B) are consistent. (A) Misexpression of kni is seen as a thinner stripe 3, and stripe 3 is also cut when there are 2 copies of the transgene. (B) Misexpression of hb results in bulging, bending and cutting of stripe 3. Stripe 7 bulges when there are 2 copies of the transgene. Stripe 2 remains unaffected in both cases.