Every day, millions of cells in our body divide to maintain essential tissue functions. Errors in cell division can lead to developmental disorders or cancer. The research of the unit is focused on molecular mechanisms of cell divison and quality control in normal and cancer cells to understand tumor-suppressive mechanisms and identify biomarkers that confer a cancer-specific vulnerability to chemical drugs. The unit combines high throughput imaging, gene editing and genome wide screens to open new avenues for therapeutic development.

Using a mouse model, the Cell Signal Unit explores the cause of various diseases that include cancer, neuronal disorders, immunological diseases, and diabetes/obesity at the molecular level....

The Chemistry and Chemical Bioengineering Unit develops methods and strategies for the construction of organic molecules that contribute to biomedical research and drug discovery.

The Marine Structural Biology Unit uses cryoelectron tomography and single particle cryoelectron microscopy to understand various aspects of coral biology in unprecedented detail.

We develop methods for single-molecule imaging and analysis, and apply them to unravel the mechanisms by which the cellular plasma membrane perform signaling and synaptic transmission.

Nucleic acids DNA and RNA are fundamental building blocks of life. These biomolecules display remarkable chemical functions such as information storage, catalysis, and molecular recognition....

The Protein Engineering and Evolution Unit applies chemical approaches, evolutionary methods and protein engineering to study and manipulate protein functions.