Our research bridges nanoscale defect mechanics and macroscale manufacturing to drive the sustainability of engineering materials production. By integrating multiscale computational mechanics, atomistic modeling, and advanced in-situ characterization, we decode the coupled defect mechanics and chemical kinetics in the solid phase. To translate these fundamental insights into scalable engineering solutions, we develop physics-informed, data-driven platforms that connect nano- to micro-scale phenomena with industrial process dynamics. Based on rigorous understanding of nano-mechanics and chemical kinetics, we aim to accelerate the design of next-generation technologies in green metallurgy and energy storage materials.