Publications

2025

Large-scale identification of plasma membrane repair proteins revealed spatiotemporal cellular responses to plasma membrane damage

Y Yamazaki, K Kono
eLife 14

Time-resolved miRNA-mRNA integrated analysis reveals the miRNA-mRNA networks underlying plasma membrane damage-dependent senescence and DNA damage response-dependent senescence in WI-38 normal human fibroblasts

Y Chiu, R Ishida, Y Moriyama, J Grašič, K Kono
RNA biology

Time-resolved transcriptomics of S. cerevisiae and S. pastorianus in response to plasma membrane stresses

Y Yamazaki, F Omura, E Ono, N Kamada, K Kono
Scientific Data 12 (1), 1246

Knockdown of CNOT3, a subunit of the CCR4-NOT deadenylase complex, sensitizes A549 human non-small cell lung cancer cells to senescence-inducing stimuli

A Maipas, A Sato, Y Moriyama, T Yamamoto, K Kono
Biochemical and Biophysical Research Communications 748, 151294

Discovery and identification of a novel yeast species, Hanseniaspora drosophilae sp. nov., from Drosophila in Okinawa, Japan

T Seike, H Takekata, K Kono, N Sakata, H Kotani, C Furusawa, F Matsuda
International Journal of Systematic and Evolutionary Microbiology 75 (2), 006661

2024

Exocytic plasma membrane flows remodel endoplasmic reticulum–plasma membrane tethering for septin collar assembly

S Sugiyama, K Kono
Science Advances 10 (11), eadj1512

Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts

K Suda, Y Moriyama, N Razali, Y Chiu, Y Masukagami, K Nishimura, ...
Nature Aging 4 (3), 319-335

Cytoplasmic zoning by protein phase transition after membrane permeabilization

S Sugiyama, K Suda, K Kono
The Journal of Biochemistry 175 (2), 147-153

2023

FMRP Long-Range Transport and Degradation Are Mediated by Dynlrb1 in Sensory Neurons

SE El-Agamy, L Guillaud, K Kono, Y Wu, M Terenzio
Molecular & Cellular Proteomics 22 (11), 100653

2022

Clathrin-mediated trafficking of phospholipid flippases is required for local plasma membrane/cell wall damage repair in budding yeast

Y Yamazaki, K Kono
Biochemical and biophysical research communications 606, 156-162

真核微生物におけるシグナル伝達と代謝の接点を探る-発酵調節の根源的な理解に向けて-細胞創傷治癒の分子基盤とその帰結

K KONO
生物工学会誌 98 (4), 181-182

2019

Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase

K Nishimura, Y Johmura, K Deguchi, Z Jiang, KSK Uchida, N Suzuki, ...
Nature Communications 10 (1), 981

2017

A new cell cycle checkpoint that senses plasma membrane/cell wall damage in budding yeast

K Kono, AE Ikui
Bioessays 39 (4), 1600210

Ypk1 and Ypk2 kinases maintain Rho1 at the plasma membrane by flippase-dependent lipid remodeling after membrane stresses

R Hatakeyama, K Kono, S Yoshida
Journal of cell science 130 (6), 1169-1178

2016

Local and acute disruption of the yeast cell surface

K Kono, H Okada, Y Ohya
Cold Spring Harbor Protocols 2016 (8), pdb. prot085266

Examination and disruption of the yeast cell wall

H Okada, K Kono, AM Neiman, Y Ohya
Cold Spring Harbor Protocols 2016 (8), pdb. top078659

Plasma membrane/cell wall perturbation activates a novel cell cycle checkpoint during G1 in Saccharomyces cerevisiae

K Kono, A Al-Zain, L Schroeder, M Nakanishi, AE Ikui
Proceedings of the National Academy of Sciences 113 (25), 6910-6915
 

PP1-dependent formin Bnr1 dephosphorylation and delocalization from a cell division site

M Orii, K Kono, HI Wen, M Nakanishi
PLoS One 11 (1), e0146941

2012

Regulation of the formin Bnr1 by septins anda MARK/Par1-family septin-associated kinase

SM Buttery, K Kono, E Stokasimov, D Pellman
Molecular biology of the cell 23 (20), 4041-4053

Proteasomal Degradation Resolves Competition between Cell Polarization and Cellular Wound Healing

K Kono, Y Saeki, S Yoshida, K Tanaka, D Pellman
Cell 150 (1), 151-164

2008

G1/S Cyclin-dependent Kinase Regulates Small GTPase Rho1p through Phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae

K Kono, S Nogami, M Abe, M Nishizawa, S Morishita, D Pellman, Y Ohya
Molecular biology of the cell 19 (4), 1763-1771

2006

Polo-Like Kinase Cdc5 Controls the Local Activation of Rho1 to Promote Cytokinesis

S Yoshida, K Kono, DM Lowery, S Bartolini, MB Yaffe, Y Ohya, D Pellman
Science 313 (5783), 108-111

2005

Involvement of actin and polarisome in morphological change during spore germination of Saccharomyces cerevisiae

K Kono, R Matsunaga, A Hirata, G Suzuki, M Abe, Y Ohya
Yeast 22 (2), 129-139

2002

Dissection of Upstream Regulatory Components of the Rho1p Effector, 1,3-β-Glucan Synthase, in Saccharomyces cerevisiae

M Sekiya-Kawasaki, M Abe, A Saka, D Watanabe, K Kono, ...
Genetics 162 (2), 663-676

bioRxiv

Time-resolved transcriptomic profiling of senescence-associated secretory phenotype (SASP) in multiple senescent cell subtypes

N Razali, Y Moriyama, Y Chiu, K Suda, K Kono
BioRxiv, 2022.06. 27.497690