Research Topics
Memory Engram, Hippocampus, Systems Neuroscience, Neuronal and Non-Neuronal Remodeling
Approaches
in vivo electrophysiology (tetrode and silicon probe), in vivo imaging, genetic tagging, electron microscopy (TEM & SEM), correlative light and electron microscopy (CLEM), artificial intelligence, artificial hibernation
Major Publications
Artificial hibernation uncovers distinct synaptic engram architecture for memory retention
YJ Lin, A Takahashi Nakazato, K Tsutsumi, T Takahashi, D Mercier, H Ashitomi, MC Chiang, M Haberl, M Uytiepo, A Maximov, Y Makino,
T Nemoto, R Enoki, A Hirano, K Soga, S Looprasertkul, N Ohno, Y Kubota, T Sakurai, KZ Tanaka
2025, bioRxiv 2025.12.09.692927; https://doi.org/10.64898/2025.12.09.692927
Single-cell bioluminescence imaging of deep tissue in freely moving animals
Satoshi Iwano, Mayu Sugiyama, Hiroshi Hama, Akiya Watakabe, Naomi Hasegawa, Takahiro Kuchimaru, Kazumasa Z. Tanaka, Megumu Takahashi, Yoko Ishida, Junichi Hata, Satoshi Shimozono, Kana Namiki, Takashi Fukano, Masahiro Kiyama, Hideyuki Okano, Shinae Kizaka-Kondoh, Thomas J. McHugh, Tetsuo Yamamori, Hiroyuki Hioki, Shojiro Maki, Atsushi Miyawaki
2018, Science, 359(6378), 935–939. https://doi.org/10.1126/science.aaq1067
The hippocampal engram maps experience but not place
Kazumasa Z. Tanaka, Hongshen He, Anupratap Tomar, Kazue Niisato, Arthur J. Y. Huang, and Thomas J. McHugh
2018, Science, 361(6400), 392–397. https://doi.org/10.1126/science.aat5397
Cortical representations are reinstated by the hippocampus during memory retrieval.
Kazumasa Z Tanaka, Aleksandr Pevzner, Anahita B Hamidi, Yuki Nakazawa, Jalina Graham, Brian J Wiltgen
2014, Neuron, 84(2), 347–354. https://doi.org/10.1016/j.neuron.2014.09.037
External Grants
- CREST, Understanding and Controlling the Biological Vitality for Life Function
(2024 - 2030)
- Grants-in-Aid for Transformative Research Areas, Hibernation Biology 2.0, Core Member
(2023 - 2028)
- Grant-in-Aid for Scientific Research (B)
(2020 - 2023)
- Grant-in-Aid for Young Scientists
(2019 – 2021)
- The Nakajima Foundation, Research Funding for Early-Career Scientists
(2019 – 2020)
- Takeda Science Foundation, Visionary Research Grant
(2017 - 2018)
- The Uehara Memorial Foundation, Research Grant
(2017)
- Brain Science Foundation, Research Grant
(2017)
