Model of the cellular response to plasma membrane damage in budding yeast

A new model of the cellular response to plasma membrane damage. Within ~2 minutes of damage, Pkc1 proteins flood to the damage site to stabilize the puncture, and other proteins involved in the growth of the bud tip get recruited for repair duty. Some are involved in exocytosis, fusing vesicles of lipids and other materials to the damaged membrane, while others are later involved in endocytosis, removing excess material and restoring the normal function of the now-sealed site. Finally, the remaining proteins are recruited back to the budding site, returning to their duty of growing the yeast bud tip.