5 Feb 2019
Much like shoelaces or dangly necklaces, DNA strands can tangle up in unruly knots. Specialized enzymes keep DNA organized when cells divide, so the cells split smoothly and don’t get stuck. But in...
Type: News Article
31 Jan 2019
(Left to right) Prof. Mitsuhiro Yanagida, technician Orie Arakawa, and Dr. Norihiko Nakazawa of the G0 Cell Unit authored a paper on the enzyme DNA topoisomerase II (topo II) a critical target...
Type: Photo
31 Jan 2019
With DNA topoisomerase II (topo II) intact, DNA in fission yeast cells replicates normally and is split evenly between two daughter cells (left). When under the effects of anti-cancer drug ICRF-193,...
Type: Photo
31 Jan 2019
Casein kinase II (CKII) phosphorylates DNA topoisomerase II (topo II), thus activating the ATPase domain of the enzyme (left). This activation cancels the effects of anti-cancer drug ICRF-193. If...
Type: Photo
31 Jan 2019
DNA topoisomerase II (topo II), a master regulator of DNA metabolism for cell proliferation, is a critical target for anti-cancer therapy.
Type: Photo
31 Jan 2019
Fasting may help people lose weight, but new research suggests going without food may also boost human metabolic activity, generate antioxidants, and help reverse some effects of aging. Scientists at...
Type: Press release
30 Jan 2019
Prof. Mitsuhiro Yanagida and Dr. Takayuki Teruya of the G0 Cell Unit recently published a paper with Kyoto University on the effects of fasting on the human metabolism. The study suggest novel health...
Type: Photo
30 Jan 2019
A study by the G0 Cell Unit and Kyoto University researchers suggests that fasting, which puts the body in “starvation mode,” leads to fuel substitution, antioxidation, increased mitochondrial...
Type: Photo
15 Aug 2018
Scientists from the Okinawa Institute of Science and Technology Graduate University (OIST), have identified 85 genes essential for fission yeast cells at rest, under nutritionally limited...
Type: Press release
3 Jul 2018
From left to right: Ms. Kaori Serakaki of the OIST Media Section (who provided support in creating illustrations of the cohesin models), Dr. Norihiko Nakazawa, Mrs. Li Wang (who gave technical...
Type: Photo
3 Jul 2018
These diagrams compare the two models of the cohesin protein’s structure. The ring model has distinct “head” and “hinge” features at opposite ends of the molecule, whereas the hold-and-release model...
Type: Photo
3 Jul 2018
A diagram of the protein complex cohesin in its assumed ring-shaped configuration. The scissors represent the action of the enzyme Cut1, which breaks apart the molecule to release DNA.
Type: Photo
Subscribe to G0 Cell Unit (Mitsuhiro Yanagida)