24 Apr 2020
Hailed as one of the most important medical advances, the discovery of general anesthetics – compounds which induce unconsciousness, prevent control of movement and block pain – helped transform...
Type: News Article
24 Apr 2020
When vesicles fuse with the presynaptic membrane during exocytosis, the synaptic vesicle membrane is incorporated into the terminal membrane, increasing its surface area. During endocytosis, vesicles...
Type: Photo
24 Apr 2020
The experiment used genetically modified mice that had a light sensitive protein (green circle), usually found in the eye, embedded in the membrane of the presynaptic neurons in one area of the brain...
Type: Photo
24 Apr 2020
The large size of the calyx of Held allows scientists to visualize and manipulate the synapse. The electrodes touching the neurons can be used to evoke and record electrical signals. The frequency of...
Type: Photo
24 Apr 2020
(1) A nerve impulse arrives. (2) This causes calcium ion channels to open, resulting in an influx of calcium ions in the terminal. (3) This causes synaptic vesicles to fuse with the terminal membrane...
Type: Photo
25 Dec 2019
Researchers in the Cellular and Molecular Synaptic Function Unit at the Okinawa Institute of Science and Technology Graduate University (...
Type: News Article
25 Dec 2019
Fig 5: The authors of the new study, published in Journal of Neuroscience. From left to right: Dr Lashmi Pyriya, Dr. Kohgaku Eguchi, Dr Laurent Guillaud, Professor Tomoyuki Takahashi, Dr. Han-Ying...
Type: Photo
25 Dec 2019
Fig 4 Left, Experimental protocol of simultaneous recording of APs from presynaptic (right crescent) and postsynaptic (left round) structures. Middle, Postsynaptic APs evoked by presynaptic APs (not...
Type: Photo
25 Dec 2019
Fig 3 Effects of MT or F-actin depolymerization on the rate of release site replenishment.  A, Time course of SV replenishment assayed from recovery of EPSCs from synaptic depression.  MT...
Type: Photo
25 Dec 2019
Fig 2 Co-localization of MTs (green) and SVs (red and yellow) in a calyx of Held presynaptic terminal. 3D reconstruction of STED image. About half SVs (red) are located within 100 nm from MTs with...
Type: Photo
25 Dec 2019
Fig 1 (A) Axon and presynaptic terminal. (B) Synaptic transmission. The thick filament “microtubules” (MTs) made of tubulin polymers and the thin filament “F-actin” made of actin polymers are...
Type: Photo
26 Mar 2018
The chemical structure of “caged” GABA (left) and free GABA (right). After UV illumination, GABA is released from the compound.
Type: Photo
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