15 Oct 2021 - 11:51
The video shows two mice, one of which is normal weight. The other mouse is obese, due to a loss of XRN1 in the forebrain. These mice were part of a recent iScience study, with the video appearing in...
Type: Video
15 Oct 2021 - 11:44
In a new study published in iScience, researchers created mutant mice without XRN1 in the forebrain. XRN1 is a protein that plays a crucial role in degrading mRNA. The scientists found that...
Type: Photo
15 Oct 2021 - 10:46
Highlights Obesity is an increasingly serious public health issue, but the underlying molecular causes are not fully understood Now, scientists have found that loss of the protein, XRN1, which is...
Type: Press release
28 Aug 2020 - 18:00
A protein that’s common throughout the body plays a key role in regulating glucose levels, says new research conducted in the Cell Signal Unit...
Type: Press release
28 Aug 2020 - 00:00
The researchers from the Cell Signal Unit at OIST. From left, Dr. Akiko Yanagiya, Dr. Dina Mostafa, and Professor Tadashi Yamamoto.
Type: Photo
28 Aug 2020 - 00:00
Mice lacking CNOT3 in pancreatic beta cells have fewer insulin-producing cells, leading to diabetes.
Type: Photo
18 Dec 2015 - 02:15
Ever imagined you could eat all the mouthwatering, festive food during winter holidays and never worry about an expanding waistline? For many people throughout the world, being overweight or worse...
Type: Press release
18 Dec 2015 - 02:00
The animation illustrates OIST research’s findings in obesity: the degradation of Ucp1 mRNA in fat cells is mediated by Tob and Cnot7.  
Type: Video
4 Dec 2015 - 16:24
Recent research has shown that the cells in our bodies teeter on the brink of death. They possess intricate molecular mechanisms that promote either suicide or survival. The concept is known as...
Type: News Article
Cell Undergoing Necroptosis
4 Dec 2015 - 16:09
CNOT3-depleted mouse cell undergoes necroptosis. The cell membrane swells and later breaks, leaking its contents into the intercellular space.
Type: Photo
Suppression of the mRNA turn-over leads to necroptosis
4 Dec 2015 - 16:06
Intact CCR4-NOT complex (on the left) suppresses the messenger RNAs (mRNAs) encoding RIPK1 and RIPK3 proteins, thereby aiding cell survival. CNOT3-depleted cells, in which the CCR4-NOT complex does...
Type: Photo
Dr Toru Suzuki
4 Dec 2015 - 16:01
Dr Suzuki, group leader at the Cell Signal Unit at OIST
Type: Photo
Subscribe to Cell Signal Unit (Tadashi Yamamoto)