18 Sep 2020
In a simple behavioral experiment, rats choose between better quality food that is delivered in conjunction with an uncomfortably bright light, or lower quality food with a less bright light. Signals...
Type: Photo
18 Sep 2020
Neurons from the ventromedial thalamus (red area) extend into the prelimbic cortex (blue area) which is a region within the prefrontal cortex (grey area).
Type: Photo
18 Sep 2020
Every day, we make hundreds of decisions. While most are small and inconsequential, like choosing what to eat or wear, others are more complex and involve weighing up potential costs and benefits,...
Type: Press release
18 Feb 2019
The tell-tale tremors of Parkinson’s disease emerge from abnormal activity in a brain region crucial for voluntary movement. Using a mouse model of the disease, researchers at the Okinawa Institute...
Type: News Article
5 Feb 2019
In response to continuous optogenetic stimulation to their striatal output neurons, mice turned in one direction, as is typical of mouse models of Parkinson’s disease. When exposed to pulsed...
Type: Photo
5 Feb 2019
Researchers in the Brain Mechanism for Behavior Unit stimulated the brains of mice bred to model Parkinson’s disease, finding that their striatal neurons reacted differently to different patterns of...
Type: Photo
Connectivity map of a Multi-electrode Array (MEA) showing electrophysiological activity between the electrodes.
19 Jun 2015
The top half of the MEA housed the compartment containing cells from the mouse cortex.  The bottom half housed the compartment containing cells from the mouse striatum. When the axons reaching...
Type: Photo
OIST researchers who recreated a working corticostriatal network in culture
19 Jun 2015
Seated: From left to right, Marianela Garcia-Munoz, Professor Gordon Arbuthnott, Head of the Brain Mechanism for Behaviour Unit and Reuven Pnini.  Standing: From left to right, Eddy Taillefer,...
Type: Photo
19 Jun 2015
Mapping the human brain’s network of interconnections, known as the connectome is typically done with help from computational tools because recreating interconnections between different brain...
Type: News Article
Dr. Violeta Lopez-Huerta and Professor Gordon Arbuthnott of the OIST Brain Mechanism for Behaviour Unit
11 Mar 2015
First author Dr. Violeta Lopez-Huerta and Professor Gordon Arbuthnott of the OIST Brain Mechanism for Behaviour Unit in the lab where they mapped the neostriatum. 
Type: Photo
Panoramic view of a mouse brain including the neostriatum.
11 Mar 2015
The virus stains in red the connections leaving the neostriatum wherever it is expressed, but not everywhere as was expected.  In the engineered mouse strain the neurons were already fluorescent...
Type: Photo
17 Nov 2014
Synapse, the name for the signal-receiving site on a neuron, comes from the Greek word for contact. Neuroscientists used to maintain that neurons form one-to-one relationship to contact one another....
Type: News Article
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