Epigenetics
This course provides an overview of the principles of epigenetics to students with background of molecular biology and genetics.
By the end of this course, students will be able to:
Explain the molecular mechanisms of epigenetic regulation, including histone modifications, DNA methylation, and RNA interference.
Analyze the role of transposable elements, dosage compensation, and chromatin structure in gene regulation and genome evolution.
Evaluate the impact of epigenetic reprogramming on stem cell biology and disease development.
Interpret and critique original research publications related to epigenetic phenomena.
Epigenetic regulation of gene activity is essential for development and response to environmental changes in living organisms. Discover fundamental principles and key concepts of epigenetics, including the specific molecular mechanisms and structural changes. Examine these changes in the context of modifying factors such as transposable elements, RNA interference, and dosage compensation. Discuss recent advances in epigenetic reprogramming, stem cell applications, and the influence of epigenetic changes on disease. Critically review and discuss original research publications about epigenetic phenomena.
Introduction to Epigenetics
Histone variants and modifications
DNA methylation
RNA interference and small RNA
Regulation of chromosome and chromatin structure
Transposable elements and genome evolution I
Transposable elements and genome evolution II
Epigenetic regulation of development I
Epigenetic regulation of development II
Genome imprinting
Dosage compensation I
Dosage compensation II
Epigenetic reprogramming and stem cells
Epigenetics and disease
Epigenomics
Participation 50%; Presentation, 50%.
Advanced undergraduate Cell Biology and Genetics
Epigenetics, by Allis, Jenuwein, Reinberg, Caparros (2006) Cold Spring Harbor Laboratory Press
Molecular Biology of the Cell, 5 edn, by Alberts et al. (2007) Garland Science
Introduction to Genetic Analysis, 10 edn, by Griffiths et al. (2010) W.H. Freeman and Company