Detection and regulation of ssRNA are of great interest in synthetic and cell biology. Developing a programmable and sequence-specific ssRNA-binding protein would facilitate such studies.

Thanks to the recent advances in machine-learning-based computational tools for modeling proteins, designing complex structures involving both protein and non-protein molecules, such as DNA and RNA, is becoming more and more accessible. Leveraging the state-of-the-art computational tools, we aim to design programmable, sequence-specific RNA binders. In this talk, I will present our design approach and our initial experimental screening results.

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Dr. Iori Morita, SNSF Postdoctoral Fellow, Institute of Science and Technology Austria (ISTA) 

https://ista.ac.at/en/research/praetorius-group/