I am an applied mathematician with over a decade of experience in mathematical physiology and systems biology. I specialise in modelling complex biological processes, including calcium signalling, cellular electrophysiology, and cancer cell metabolism. My work includes four and a half years at the Institute of Metabolism and Systems Research at the University of Birmingham, England, where I focused on modelling cancer biology. Currently, I am pursuing a theoretical approach to cellular metabolism, aiming to develop a fundamental theory to improve model accuracy and provide deeper insights for oncometabolism.
Selected research:
[1] Vera-Sigüenza, Elías, et al. "A mathematical model of fluid transport in an accurate reconstruction of parotid acinar cells." Bulletin of mathematical biology 81 (2019): 699-721.
[2] Vera-Sigüenza, Elías, et al. "Pyruvate from bone marrow mesenchymal stem cells supports myeloma redox homeostasis and anabolism." bioRxiv (2024): 2024-08.
[3] Vera-Sigüenza, Elías, et al. "A Mathematical Exploration of SDH-b Loss in Chromaffin Cells." Bulletin of Mathematical Biology 87.4 (2025): 1-36.
Ph.D. 2020 (University of Auckland New Zealand)