Shannon

Shannon W

Shannon Welch is a project researcher at Tokyo College, one of the University of Tokyo's Institutes for Advanced Study. Prior to this appointment, she received her PhD in Literature with a specialization in Critical Gender Studies from the University of California, San Diego in December 2022. Her research focuses on Japanese Brazilian and Okinawan Brazilian literatures, which she reads in the context of Japanese imperialism and Brazilian capitalist modernity with attention to questions of race, gender, sexuality, and coloniality. 

Date:
26 April 2025

Copyright OIST (Okinawa Institute of Science and Technology Graduate University, 沖縄科学技術大学院大学). Creative Commons Attribution 4.0 International License (CC BY 4.0).

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Comparison between computational modeling and actual embryo on gene regulation in the entire fruit fly embryo

  Dr. Garth Ilsley, in Prof Nicholas Luscombe’s Genomics and Regulatory Systems Unit at OIST and Assistant Professor Angela DePace at Harvard Medical School succeeded in modelling early regulation of development in the fruit fly Drosophila using a statistical approach that accurately predicts gene expression in the whole embryo. This study was published in the open access journal, eLIFE, on August 6th. This figure is comparison of calculated results from the model (upper half) with image data from an actual embryo (lower half). It can be seen that the mutations in stripes 3 and 7 due to the misexpression of kni (A) and hb (B) are consistent. (A) Misexpression of kni is seen as a thinner stripe 3, and stripe 3 is also cut when there are 2 copies of the transgene. (B) Misexpression of hb results in bulging, bending and cutting of stripe 3. Stripe 7 bulges when there are 2 copies of the transgene. Stripe 2 remains unaffected in both cases.