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In FY2022, Kono unit members received four prizes (see below). Overall, we investigated the molecular mechanisms and physiological consequences of plasma membrane damage using normal human fibroblasts, mice, and budding yeast. We found and reported that 1) plasma membrane damage induces cellular senescence (bioRxiv), and 2) the time-resolved transcriptomic profiling of senescence-associated secretory phenotype (SASP) raises a possibility that plasma membrane damage-dependent senescent cells are associated with multiple paracrine/autocrine functions including tissue repair in vivo (bioRxiv). Based on this and other findings, we started multiple collaboration projects with both academic and industrial partners. We also contributed to the researcher community by hosting the 55th Annual Meeting of Yeast Genetics Forum.