ADSL enzymatic activities and protein sequences

In the study, the researchers examined the activity of ADSL by measuring the concentration of protein substrates SAICAr and S-Ado (in red), which increase when ADSL activity decreases. Below, the amino acid sequence differences among modern humans, Neanderthals and Denisovans, chimpanzees, and mice are shown. The change at position 429 is the only difference between modern humans and ancestral hominins. The substitution in mice on position 428 (in red) was not found to alter the activity of ADSL.