5 Feb 2019
In response to continuous optogenetic stimulation to their striatal output neurons, mice turned in one direction, as is typical of mouse models of Parkinson’s disease. When exposed to pulsed...
Type: Photo
5 Feb 2019
Researchers in the Brain Mechanism for Behavior Unit stimulated the brains of mice bred to model Parkinson’s disease, finding that their striatal neurons reacted differently to different patterns of...
Type: Photo
5 Feb 2019
Much like shoelaces or dangly necklaces, DNA strands can tangle up in unruly knots. Specialized enzymes keep DNA organized when cells divide, so the cells split smoothly and don’t get stuck. But in...
Type: News Article
31 Jan 2019
(Left to right) Prof. Mitsuhiro Yanagida, technician Orie Arakawa, and Dr. Norihiko Nakazawa of the G0 Cell Unit authored a paper on the enzyme DNA topoisomerase II (topo II) a critical target...
Type: Photo
31 Jan 2019
With DNA topoisomerase II (topo II) intact, DNA in fission yeast cells replicates normally and is split evenly between two daughter cells (left). When under the effects of anti-cancer drug ICRF-193,...
Type: Photo
31 Jan 2019
Casein kinase II (CKII) phosphorylates DNA topoisomerase II (topo II), thus activating the ATPase domain of the enzyme (left). This activation cancels the effects of anti-cancer drug ICRF-193. If...
Type: Photo
31 Jan 2019
DNA topoisomerase II (topo II), a master regulator of DNA metabolism for cell proliferation, is a critical target for anti-cancer therapy.
Type: Photo
31 Jan 2019
The Quantum Dynamics Unit traps a 2-D layer of electrons in liquid helium, held inside a sealed chamber and cooled to nearly absolute zero. Inside the chamber, a metal plate and spherical mirror on...
Type: Photo
31 Jan 2019
Fasting may help people lose weight, but new research suggests going without food may also boost human metabolic activity, generate antioxidants, and help reverse some effects of aging. Scientists at...
Type: Press release
30 Jan 2019
Prof. Mitsuhiro Yanagida and Dr. Takayuki Teruya of the G0 Cell Unit recently published a paper with Kyoto University on the effects of fasting on the human metabolism. The study suggest novel health...
Type: Photo
30 Jan 2019
A study by the G0 Cell Unit and Kyoto University researchers suggests that fasting, which puts the body in “starvation mode,” leads to fuel substitution, antioxidation, increased mitochondrial...
Type: Photo
29 Jan 2019
For the scientists that study animal behavior, even the simplest roundworm poses huge challenges. The movement of squirming worms, flocking birds and walking humans changes from moment to moment, in...
Type: News Article
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