Cellular and Molecular Synaptic Function Unit
In the Cellular and Molecular Synaptic Function Unit, we investigate mechanisms underlying the maintenance of neurotransmission. As model preparations, we developed rodent giant presynaptic terminals visualized in slices or culture, and human synapses newly formed in neuronal culture differentiated from iPS cells. For functional analyses, we utilize patch-clamp electrophysiology, live imaging and quantitative proteomics, in combination. We aim at clarifying cellular and molecular mechanisms underlying dynamic brain functions, thereby obtaining effective therapeutic tools for neuronal diseases.