The effect of isoflurane on the giant calyx of Held
The large size of the calyx of Held allows scientists to visualize and manipulate the synapse. The electrodes touching the neurons can be used to evoke and record electrical signals. The frequency of electrical signals stimulated ranged from once every five seconds (0.2Hz) up to 200 times per second (200Hz). The higher the frequency, the stronger the effect of isoflurane on reducing postsynaptic action potentials, lowering the fidelity of the synapse.
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