Effect of isoflurane on cortico-cortical synapses in genetically modified mice

24 Apr 2020

The experiment used genetically modified mice that had a light sensitive protein (green circle), usually found in the eye, embedded in the membrane of the presynaptic neurons in one area of the brain. Flashes of blue light activated the protein and stimulated the transmission of sequences, or ‘trains’, of action potentials along the presynaptic neurons to another area of the brain at two different frequencies – twice per second (0.2Hz) and twice every ten seconds (2Hz). The larger reduction by isoflurane on higher frequency transmission was recorded by a silicon probe inserted into the brain.

Free for anyone to re-use, but must be credited to OIST.
This work is licensed under a Creative Commons Attribution 2.0 Generic License.

Download full-resolution image