Molecular Cryo-Electron Microscopy Unit Helps Reveal Structure of Cancer Killing Virus
Japanese and International Media
Tuesday, 30. October 2018 - 9:45
An international team of researchers at OIST and University of Otago have used the Nobel-winning cryo-electron microscopy method to reconstruct the structure of Seneca Valley virus, abbreviated SVV, at near-atomic resolution. The structure shows how the virus binds to its cellular receptor, the Anthrax toxin receptor. Type 1 of this receptor is selectively expressed in up to 60% of human cancer cells and allows the virus to infect and destroy them while not affecting healthy cells.