ATP regulates cytosolic viscosity in axons schematic

A diagram summarizing the main findings of the paper, showing how ATP regulates viscosity, and is in turn regulated by NMN.

ATP has been found to regulate cytosolic viscosity and thereby protein aggregation, which can lead to synaptic dysfunction and neurodegeneration. NMN (nicotinamide mononucleotide) is a precursor to NADH (nicotinamide adenine dinucleotide), which in turn is used by the mitochondria to synthesize ATP. By increasing the availability of NMN, cytosolic viscosity may therefore be reduced.

Date:
24 April 2025
Credit:
Laurent Guillaud / OIST

Copyright OIST (Okinawa Institute of Science and Technology Graduate University, 沖縄科学技術大学院大学). Creative Commons Attribution 4.0 International License (CC BY 4.0).

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